Appraisal of anti-inflammatory potential of the clubmoss, Lycopodium clavatum L.

Orhan İ., Kupeli E., Sener B., Yesilada E.

Journal of Ethnopharmacology, vol.109, no.1, pp.146-150, 2007 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 109 Issue: 1
  • Publication Date: 2007
  • Doi Number: 10.1016/j.jep.2006.07.018
  • Journal Name: Journal of Ethnopharmacology
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.146-150
  • Keywords: Lycopodium clavatum, Lycopodiaceae, clubmoss, anti-inflammatory, acetic acid-induced increased capillary penneability, alkaloid, HUPERZINE-A, OTITIS-MEDIA, ALKALOIDS, MEDICINES, CHILDREN, THERAPY, DRUG
  • Gazi University Affiliated: Yes


Studies on four extracts prepared with petroleum ether, chloroform, ethyl acetate and methanol as well as the alkaloid fraction from the aerial parts of Lycopodium clavatum L. of Turkish origin using acetic acid-induced increase in capillary permeability assessment in mice revealed that only the chloroform extract and the alkaloid fraction displayed marked anti-inflammatory effect at a dose of 500 mg/kg having percentage of inhibition 24.3 and 32.1, respectively, as compared to indomethacin, which exhibited 44.6% of inhibition at 10 mg/kg dose. Bioassay-guided fractionation of the alkaloid fraction of Lycopodium clavatum revealed that the alkaloidal-type of compounds might possibly be responsible for the anti-inflammatory activity of the extract, which supports the folk medicinal utilization of the plant. Gas chromatographic-mass spectrophotometric analysis of the active alkaloid fraction revealed that lycopodine (84.5%) is the major component. © 2006 Elsevier Ireland Ltd. All rights reserved.