Molecular diversity in the bioactive compounds from turkish plants-evaluation of acetylcholinesterase inhibitory activity of Fumaria species

Sener B., Orhan İ.

Journal of the Chemical Society of Pakistan, cilt.26, sa.3, ss.313-315, 2004 (SCI Expanded İndekslerine Giren Dergi) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 26 Konu: 3
  • Basım Tarihi: 2004
  • Dergi Adı: Journal of the Chemical Society of Pakistan
  • Sayfa Sayıları: ss.313-315


Acetylcholinesterase inhibitory activity of 10 Fumaria species (F. asepala, F. capreolata, F. cilicica, F. densiflora, F. judaica, F. kralikii, F. macrocarpa, F. parviflora, F. petteri subsp. thuretii and F. vaillantii) was measured by a modified spectrophotometric method developed by Ellman. All of the extracts displayed high inhibitory activity, ranging between 84.98±1.07 % and 96.89±0.17 %. The results were compared to galanthamine as the reference compound. Bioactivity-directed fractionation of F. vaillantii afforded a number of isoquinoline-type alkaloids as the active constituents identified by he means of spectroscopic techniques.