Akademik Veri Yönetim Sistemi
TRAKYA UNIVERSITY JOURNAL OF NATURAL SCIENCES, cilt.24, sa.2, ss.101-116, 2023 (ESCI)
Peritoneal adhesion occurs as a result of surgery, peritoneal injury, peritonitis,
hypoxia, and ischemia. Surgical trauma causes many pathophysiological processes which
include inflammation, oxidation, coagulation, fibrinolysis, cell proliferation, and apoptosis.
After intra-abdominal operations, the adhesion tissue may occur on the peritoneal surface due
to low fibrinolytic activity. This may result in permanent excessive adhesion tissue bands
instead of properly formed fibrin structures. Therefore, anticoagulant, thrombolytic, and
fibrinolytic activities have a key role in preventing peritoneal adhesion. Indeed, several
studies have been conducted to find out new and effective agents against intra-abdominal
adhesion. Thus, revealing the causes, development processes, and investigation techniques
are highly important for designing and conducting such scientific studies. In this context, this
study aims to summarize the pathophysiological processes of above-mentioned activities and
to emphasize their importance in the peritoneal adhesion model as well as to explain the
evaluation methods, particularly in terms of the investigation of natural products.