The association of clinicopathologic features and peripheral blood parameters with high PD-L1 expression in non-small cell lung cancer Küçük hücreli dışı akciğer kanserinde yüksek pd-l1 düzeyi ile ilişkili klinikopatolojik faktörlerin ve periferik kan parametrelerinin belirlenmesi
Tuberkuloz ve Toraks, cilt.68, sa.2, ss.118-125, 2020 (ESCI, Scopus, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 68 Sayı: 2
- Basım Tarihi: 2020
- Doi Numarası: 10.5578/tt.69182
- Dergi Adı: Tuberkuloz ve Toraks
- Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, CAB Abstracts, EMBASE, MEDLINE, TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.118-125
- Anahtar Kelimeler: NLR, PD-L1, PLR, SII, immune check-point inhibitors
- Gazi Üniversitesi Adresli: Evet
Özet
© 2020 by Tuberculosis and Thorax.Introduction: Programmed death ligand 1 (PD-L1) is a marker that widely used for prediction of response to immunotherapy. Dynamic alteration of PD-L1 expression are the major problems for reflection of the actual status of the PD-L1. So, we aimed to investigate the factors that may be associated with PD-L1 expression in lung cancer. Materials and Methods: The patients diagnosed with non-small cell lung cancer were enrolled, retrospectively. The patients were stratified according to PD-L1 expression level as ≥ 50% and < 50%. Results: Totally, 217 patients were enrolled. The clinicopathologic features were similar between two groups, except the amount of cigarette consumpti-on. Neutrophil-lymphocyte ratio, platelet-lymphocyte ratio, and systemic immune-inflammmotry index were found significantly lower in PD-L1 ≥ 50% (p< 0.001, p= 0.006 and p= 0.003, respectively) and also negatively correlated with PD-L1 level (rho=-0.255, p< 0.001; rho=-0.17, p= 0.013; rho=-0.185, p= 0.006, respectively). Conclusion: According to the results of our study, peripheral blood parameters can be used to the prediction of the high PD-L1 expression and can be used for reflection of current PD-L1 expression.