The association of clinicopathologic features and peripheral blood parameters with high PD-L1 expression in non-small cell lung cancer Küçük hücreli dışı akciğer kanserinde yüksek pd-l1 düzeyi ile ilişkili klinikopatolojik faktörlerin ve periferik kan parametrelerinin belirlenmesi

Bilgin B., Hizal M., Yücel Ş., ŞENDUR M. A. N., AKYÜREK N., AKINCI M. B., ...Daha Fazla

Tuberkuloz ve Toraks, cilt.68, sa.2, ss.118-125, 2020 (ESCI) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 68 Sayı: 2
  • Basım Tarihi: 2020
  • Doi Numarası: 10.5578/tt.69182
  • Dergi Adı: Tuberkuloz ve Toraks
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, CAB Abstracts, EMBASE, MEDLINE, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.118-125
  • Anahtar Kelimeler: NLR, PD-L1, PLR, SII, immune check-point inhibitors
  • Gazi Üniversitesi Adresli: Evet

Özet

© 2020 by Tuberculosis and Thorax.Introduction: Programmed death ligand 1 (PD-L1) is a marker that widely used for prediction of response to immunotherapy. Dynamic alteration of PD-L1 expression are the major problems for reflection of the actual status of the PD-L1. So, we aimed to investigate the factors that may be associated with PD-L1 expression in lung cancer. Materials and Methods: The patients diagnosed with non-small cell lung cancer were enrolled, retrospectively. The patients were stratified according to PD-L1 expression level as ≥ 50% and < 50%. Results: Totally, 217 patients were enrolled. The clinicopathologic features were similar between two groups, except the amount of cigarette consumpti-on. Neutrophil-lymphocyte ratio, platelet-lymphocyte ratio, and systemic immune-inflammmotry index were found significantly lower in PD-L1 ≥ 50% (p< 0.001, p= 0.006 and p= 0.003, respectively) and also negatively correlated with PD-L1 level (rho=-0.255, p< 0.001; rho=-0.17, p= 0.013; rho=-0.185, p= 0.006, respectively). Conclusion: According to the results of our study, peripheral blood parameters can be used to the prediction of the high PD-L1 expression and can be used for reflection of current PD-L1 expression.