Synthesis of double C-glycoside analogue of sTn

Ress D., BAYTAŞ S., Wang Q., Munoz E., Tokuzoki K., Tomiyama H., ...Daha Fazla

JOURNAL OF ORGANIC CHEMISTRY, cilt.70, sa.20, ss.8197-8200, 2005 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 70 Sayı: 20
  • Basım Tarihi: 2005
  • Doi Numarası: 10.1021/jo050691n
  • Dergi Adı: JOURNAL OF ORGANIC CHEMISTRY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.8197-8200
  • Gazi Üniversitesi Adresli: Evet

Özet

A sTn double C-glycoside, sTn analogue 2, was synthesized using samarium chemistry developed in our laboratory. Complications in the oxidation reaction affording aldehyde acceptor were overcome by double protection of amide and the use of a room-temperature ionic liquid as solvent. Studies are underway to conjugate the sTn double C-glycoside hapten 2 to KLH carrier protein for biological evaluation as a vaccine.