Synthesis of double C-glycoside analogue of sTn


Ress D., BAYTAŞ S. , Wang Q., Munoz E., Tokuzoki K., Tomiyama H., ...More

JOURNAL OF ORGANIC CHEMISTRY, vol.70, no.20, pp.8197-8200, 2005 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 70 Issue: 20
  • Publication Date: 2005
  • Doi Number: 10.1021/jo050691n
  • Title of Journal : JOURNAL OF ORGANIC CHEMISTRY
  • Page Numbers: pp.8197-8200

Abstract

A sTn double C-glycoside, sTn analogue 2, was synthesized using samarium chemistry developed in our laboratory. Complications in the oxidation reaction affording aldehyde acceptor were overcome by double protection of amide and the use of a room-temperature ionic liquid as solvent. Studies are underway to conjugate the sTn double C-glycoside hapten 2 to KLH carrier protein for biological evaluation as a vaccine.