New therapy strategies in the management of breast cancer


Yardım-Akaydin S., Karahalil B., Nacak Baytas S.

DRUG DISCOVERY TODAY, vol.27, no.6, pp.1755-1762, 2022 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Review
  • Volume: 27 Issue: 6
  • Publication Date: 2022
  • Doi Number: 10.1016/j.drudis.2022.03.014
  • Journal Name: DRUG DISCOVERY TODAY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED)
  • Page Numbers: pp.1755-1762
  • Keywords: Breast cancer, Therapy strategies, lncRNA, miRNAs, HOTAIR, MALATI, LONG NONCODING RNA, CELL-PROLIFERATION, TUMOR-SUPPRESSOR, GENE-EXPRESSION, INVASION, GROWTH, RESISTANCE, MICRORNAS, METASTASIS, INHIBITION
  • Gazi University Affiliated: Yes

Abstract

Breast cancer (BC), the second leading cause of cancer-related deaths after lung cancer, is the most common cancer type among women worldwide. BC comprises multiple subtypes based on molecular properties. Depending on the type of BC, hormone therapy, targeted therapy, and immunotherapy are the current systemic treatment options along with conventional chemotherapy. Several new molecular targets, miRNAs, and long non-coding RNAs (lncRNAs), have been discovered over the past few decades and are powerful potential therapeutic targets. Here, we review advanced therapeutics as new players in BC management.