New therapy strategies in the management of breast cancer

Yardım-Akaydin S., Karahalil B., Nacak Baytas S.

DRUG DISCOVERY TODAY, cilt.27, sa.6, ss.1755-1762, 2022 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 27 Sayı: 6
  • Basım Tarihi: 2022
  • Doi Numarası: 10.1016/j.drudis.2022.03.014
  • Dergi Adı: DRUG DISCOVERY TODAY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED)
  • Sayfa Sayıları: ss.1755-1762
  • Anahtar Kelimeler: Breast cancer, Therapy strategies, lncRNA, miRNAs, HOTAIR, MALATI, LONG NONCODING RNA, CELL-PROLIFERATION, TUMOR-SUPPRESSOR, GENE-EXPRESSION, INVASION, GROWTH, RESISTANCE, MICRORNAS, METASTASIS, INHIBITION
  • Gazi Üniversitesi Adresli: Evet

Özet

Breast cancer (BC), the second leading cause of cancer-related deaths after lung cancer, is the most common cancer type among women worldwide. BC comprises multiple subtypes based on molecular properties. Depending on the type of BC, hormone therapy, targeted therapy, and immunotherapy are the current systemic treatment options along with conventional chemotherapy. Several new molecular targets, miRNAs, and long non-coding RNAs (lncRNAs), have been discovered over the past few decades and are powerful potential therapeutic targets. Here, we review advanced therapeutics as new players in BC management.