Colchicine intolerance in FMF patients and primary obstacles for optimal dosing

SATIŞ H., Armagan B., Bodakci E., Atas N., Sari A., Yasar Bilge N. S., ...Daha Fazla

TURKISH JOURNAL OF MEDICAL SCIENCES, cilt.50, sa.5, ss.1337-1343, 2020 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 50 Sayı: 5
  • Basım Tarihi: 2020
  • Doi Numarası: 10.3906/sag-2001-261
  • Dergi Adı: TURKISH JOURNAL OF MEDICAL SCIENCES
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, CAB Abstracts, EMBASE, MEDLINE, Veterinary Science Database, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.1337-1343
  • Anahtar Kelimeler: Colchicine, side effect, intolerance, toxicity, dose, familial Mediterranean fever, RESISTANCE, MYOPATHY, THERAPY
  • Gazi Üniversitesi Adresli: Evet

Özet

Background/aim: Colchicine is the mainstay of treatment in FMF. However, in daily practice it is not easy to maintain effective colchicine doses in a substantial number of patients due to its side effects. In this study, we aimed to investigate prevalence and risk factors for colchicine side effects that limit optimal drug dosing and cause permanent discontinuation.