Colchicine intolerance in FMF patients and primary obstacles for optimal dosing

SATIŞ H., Armagan B., Bodakci E., Atas N., Sari A., Yasar Bilge N. S., ...More

TURKISH JOURNAL OF MEDICAL SCIENCES, vol.50, no.5, pp.1337-1343, 2020 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 50 Issue: 5
  • Publication Date: 2020
  • Doi Number: 10.3906/sag-2001-261
  • Journal Name: TURKISH JOURNAL OF MEDICAL SCIENCES
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, CAB Abstracts, EMBASE, MEDLINE, Veterinary Science Database, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.1337-1343
  • Keywords: Colchicine, side effect, intolerance, toxicity, dose, familial Mediterranean fever, RESISTANCE, MYOPATHY, THERAPY
  • Gazi University Affiliated: Yes

Abstract

Background/aim: Colchicine is the mainstay of treatment in FMF. However, in daily practice it is not easy to maintain effective colchicine doses in a substantial number of patients due to its side effects. In this study, we aimed to investigate prevalence and risk factors for colchicine side effects that limit optimal drug dosing and cause permanent discontinuation.