Synthesis and Antimicrobial Activity of Novel Benzoxazoles


Arisoy M., Temiz-Arpaci O., Kaynak-Onurdag F., Ozgen S.

ZEITSCHRIFT FUR NATURFORSCHUNG SECTION C-A JOURNAL OF BIOSCIENCES, vol.67, pp.466-472, 2012 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 67
  • Publication Date: 2012
  • Doi Number: 10.5560/znc.2012.67c0466
  • Title of Journal : ZEITSCHRIFT FUR NATURFORSCHUNG SECTION C-A JOURNAL OF BIOSCIENCES
  • Page Numbers: pp.466-472
  • Keywords: Benzoxazoles, Antibacterial Activity, Antifungal Activity, BIOLOGICAL-ACTIVITY, ANALOGS

Abstract

Z. Naturforsch. 67c, 466-472 (2012); received October 17, 2011/August 3, 2012 A series of 2-(p-substituted-benzyl)-5[[4-(p-chloro/fluoro-phenyl)piperazin-1-yl]acetamido]-benzoxazoles were synthesized in need of new compounds for the fight against microbial pathogens. Their structures were elucidated by spectral techniques. These new derivatives, along with previously synthesized 2-(p-substituted-benzyl)-5-substituted-benzoxazoles, were evaluated for their antibacterial and antifungal activities against standard strains and drug-resistant isolates in comparison with ampicillin, gentamicin sulfate, ofloxacin, vancomycin, fluconazole, and amphotericin B trihydrate. The minimum inhibitory concentration (MIC) of each compound was determined by a two-fold serial dilution technique. The compounds were found to possess a broad spectrum of antimicrobial activities with MIC values of 32-256 mu g/ml. Although standard drugs were more active against the pathogenes employed in this study, the activities of the new benzoxazoles and reference drugs against drug-resistant isolates of the microorganisms were largely similar.