Association between ABCB1 gene polymorphisms and fentanyl's adverse effects in Turkish patients undergoing spinal anesthesia.

Kesimci E., Engin A. B., Kanbak O., Karahalil B.

Gene, cilt.493, sa.2, ss.273-7, 2012 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 493 Sayı: 2
  • Basım Tarihi: 2012
  • Doi Numarası: 10.1016/j.gene.2011.11.040
  • Dergi Adı: Gene
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.273-7
  • Anahtar Kelimeler: ABCB1 polymorphism, Spinal anesthesia, Fentanyl, BLOOD-BRAIN-BARRIER, P-GLYCOPROTEIN, INTESTINAL-ABSORPTION, MDR1 GENE, TRANSPORT, PHARMACODYNAMICS, POPULATION, INHIBITION, QUINIDINE, MORPHINE
  • Gazi Üniversitesi Adresli: Evet

Özet

The ATP-binding cassette transporter (ABCB1) gene product, P-glycoprotein plays an important role in the prevention of intracellular accumulation of potentially toxic substances and metabolites in various tissues. Single nucleotide polymorphisms in this gene are claimed to be correlated with changes in the function of P-glycoprotein. There is evidence that fentanyl, may be a substrate for P-glycoprotein. The aim of the study was to assess whether an association exists between ABCB1 gene polymorphism and early respiratory and sedative adverse effects of intravenous fentanyl in Turkish patients who underwent spinal anesthesia In all 83 unrelated Turkish patients were enrolled in this study. In this study, spinal anesthesia was provided and a single dose of intravenous fentanyl (2.5 mu g.kg(-1)) at the beginning of surgery was used as a sedative agent. Bispectral index, respiration rate and peripheral oxygen saturation were measured continuously and recorded throughout the study.