Usefulness of ischemia-modified albumin in predicting oxidative stress in patients with vitiligo

Atas H., Kocabiyik M., Gonul M., Ozturk Y., KAVUTÇU M.

BIOMARKERS IN MEDICINE, vol.11, no.6, pp.439-449, 2017 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 11 Issue: 6
  • Publication Date: 2017
  • Doi Number: 10.2217/bmm-2016-0259
  • Journal Name: BIOMARKERS IN MEDICINE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.439-449
  • Keywords: antioxidative system, balance, bioinformatics, contributing factors, enzyme activity, IMA, oxidative stress, usefulness, vitiligo, LIPID-PEROXIDATION, AUTOIMMUNE-DISEASE, ANTIOXIDANT STATUS, CALCIUM IMBALANCE, GENETIC-DEFECT, PATHOGENESIS, HOMOCYSTEINE, MARKER, MITOCHONDRIA, MELANIN
  • Gazi University Affiliated: Yes

Abstract

Aim: To investigate the emphasis of oxidative stress in the pathogenesis of vitiligo through an evaluation of ischemia-modified albumin (IMA). Results/methodology: IMA was of higher statistical significance in patients than in the control group (IMA: 0.57 +/- 0.2 vs 0.52 +/- 0.2.ABSU; p < 0.0001). IMA (p < 0.0001; OR: 8.9; 95% CI = 3.1-26.1) was found as an independent predictor of oxidative stress. Increases in affected body surface area and age were found to be independent risk factors for IMA. The sensitivity, specificity and positive and negative predictive values and capacity of IMA were higher than other studied biomarkers. Discussion/conclusion: IMA can be detected in the condition of oxidative stress in vitiligo; it has great potential as a biomarker of said condition, when compared with other studied biomarkers.