Circulating adrenomedullin levels in ankylosing spondylitis and Familial Mediterranean Fever


Uereten K., Oezbek M., Oeztuerk M. A., Dogru I., Dogru A., YÜREKLİ M., ...More

JOINT BONE SPINE, vol.75, no.3, pp.295-298, 2008 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 75 Issue: 3
  • Publication Date: 2008
  • Doi Number: 10.1016/j.jbspin.2007.09.011
  • Journal Name: JOINT BONE SPINE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.295-298
  • Gazi University Affiliated: Yes

Abstract

Introduction: Adrenomedullin (AM) is a 52-amino acid peptide with vasorelaxant properties. Apart from its roles on vascular tonus, AM can also contribute to inflammatory events. Plasma AM levels were elevated in connective tissue diseases and vasculitic disorders. Ankylosing spondylitis (AS) is a chronic inflammatory disease of the spine initiating in the sacroiliac joints. Familial Mediterranean Fever (FMF) is a hereditary disorder characterized by self-limiting acute attacks of fever and the presence of sustained subclinical inflammation in the attack-free periods. In this study, we investigated plasma AM levels in patients with AS and patients with FMF.