Akademik Veri Yönetim Sistemi
2ND INTERNATIONAL HISTOLOGY AND EMBRYOLOGY CONGRESS, Sakarya, Türkiye, 26 - 28 Eylül 2024, ss.125, (Özet Bildiri)
Introduction: Idiopathic male infertility occurs in 30-40% of infertile men and the cause of
reduced semen quality is unknown. The Longitudinal Investigation of Fertility and the
Environment (LIFE) study emphasised the importance of cholesterol and lipid homeostasis
for male fertility by showing that serum lipid levels can affect semen parameters, especially
sperm head morphology. The role of cholesterol in the post-testicular alteration of sperm
plasma membrane composition and dynamics is essential for fertility; however, the effect of
high cholesterol and other dyslipidaemias on fertility is still to be clarified.
Objective: Since cholesterol is the main source of steroidogenesis and plays an important role
in spermatogenesis, a potential link between serum lipids and fertility may be possible. For
this purpose, we aimed to investigate the relationship between lipid profiles and semen quality
and ICSI (intracytoplasmic sperm injection) parameters in patients admitted to Assisted
Reproductive Techniques (ART) for idiopathic male infertility.
Material and Method: The lipid profile values of 121 patients who were referred to ART for
idiopathic male infertility in the last 5 years were retrospectively analysed within 6 months
before ICSI and 36 patients who met the criteria were included in the study. Eight of the
patients had undergone TESE (testicular sperm extraction) operation due to azoospermia and
a total of 11 patients had morphology examination before ICSI. The relationship between
blood lipid profiles (LDL, VLDL, HDL, Total (T.) Cholesterol, Triglyceride values) and
semen parameters (total sperm count, motility and morphology) and ICSI parameters
(Fertilisation Rate, Good quality embryo rate) were analysed by Spearman correlation test.
Results: The median age and body mass index (BMI) of the patients were 31.5 and 28.9,
respectively. The relationship between lipid profiles of the patients and ICSI parameters is
shown in Table 1. The relationship between lipid profiles and sperm morphology percentages
of patients is shown in Table 2. The relationship between lipid profiles of the patients and
sperm motility percentage is shown in Table 3. There was no significant correlation between
blood lipid profiles and ICSI parameters (p>0.05). There was a strong negative correlation
between VLDL and acrosome anomaly. There was no significant correlation between lipid
parameters and other sperm morphological findings (p>0.05). There was also no significant
correlation between lipid profiles and sperm concentration and motility percentages (p>0.05).
Concluison: In our study, it was shown that VLDL carrying substances such as cholesterol and
vitamin E was negatively correlated with acrosome anomaly.