Which one is a risk factor for chemotherapy-induced febrile neutropenia in childhood solid tumors: Early lymphopenia or monocytopenia?

Oguz A., Karadeniz C., Citak E. C., Cil V.

PEDIATRIC HEMATOLOGY AND ONCOLOGY, vol.23, no.2, pp.143-151, 2006 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 23 Issue: 2
  • Publication Date: 2006
  • Doi Number: 10.1080/08880010500457673
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.143-151
  • Keywords: childhood solid tumors, febrile neutropenia, lymphopenia, monocytopenia, CANCER-PATIENTS, ETOPOSIDE, CHILDREN, FEVER, IFOSFAMIDE, MESNA
  • Gazi University Affiliated: No


Neutropenia is one of the undesirable effects of cancer chemotherapy, sometimes causing life-threatening events. The present study was conducted. to identify the risk factors of neutropenia. caused by chemotherapy. Between,January 2001 and March 2004, a total of 77 children. with 165 neutropenic attacks were enrolled in this study. Complete blood count was performed before chemotherapy and on days 1, 3, 5, 7, and 9 consecutively. The complete blood count results of the febrile neutropenia (FN) group were compared to those of the non-FN group. The incidence of IN was significantly higher in patients with ANC counts <= 0.5 x 10(9)/L on days 3, 5, and 7, lymphocyte counts <= 0.5 x 10(9)/L on days 7 and. 9, <= 0.7 x 10(9)/L on days 5, 7, and 9, and with monocyte counts <= 0.15 x 10(9)/L on days 7 and 9, respectively. Further statistical analysis showed that lymphocyte count <= 0.7 x 10(9)/L on day 5, and monocyte count < 0.15 x 10(9)/L on day 7 were independent risk factors for EN. The authors conclude that lymphocyte counts on the 5th day can. be more a predictive factor than monocyte count.