Tigecycline: Its potential for treatment of brucellosis


DİZBAY M. , Kilic S., Hizel K., Arman D.

SCANDINAVIAN JOURNAL OF INFECTIOUS DISEASES, vol.39, no.5, pp.432-434, 2007 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 39 Issue: 5
  • Publication Date: 2007
  • Doi Number: 10.1080/00365540601105756
  • Title of Journal : SCANDINAVIAN JOURNAL OF INFECTIOUS DISEASES
  • Page Numbers: pp.432-434

Abstract

The in vitro efficacy and synergistic activity of tigecycline in comparison with other antimicrobials used in brucellosis, were tested for 16 Brucella melitensis strains by the E-test method. Tigecycline had the lowest minimal inhibitory concentration levels, and rifampin the highest, in the study. Tigecycline also provided the better synergistic activity compared to doxycycline according to the fractional inhibitory concentration index. The results of this in vitro study suggest tigecycline as a therapeutic alternative for brucellosis. These observations need to be supported with clinical studies.