Natural and social resources are not evenly distributed in urban areas, which cause an unbalanced development and a differentiated socioeconomic structure in the urban space. In cities, where socio- economic characteristics differentiate; social status, occupational and cultural characteristics, lifestyles, income level, relative and citizenry relations cause the location of the inhabitants in different areas of the urban space and these socio- economic differences shape the space. The aim of this study is to analyse how socio- economic characteristics of the inhabitants of Bursa shape the space and what kind of differentiation these characteristics create in the urban space. In order to find out the differentiation of socio- economic and spatial structure of the city, 2000 and 2010 population data of TUIK and a detailed household questionnaire applied in the different neighbourhoods of Bursa metropolitan area in 2013 have been used. By the data gathered from the questionnaire survey, the changes in the socio- economic structures of neighbourhoods are revealed and by using chi square and principal component analysis, which of the socioeconomic variables are effective on the differentiation of the spatial structure in different neighbourhoods and the relation among these variables are evaluated.