Evaluation of anti-inflammatory and antinociceptive activity of five anatolian Achillea species

Küpeli E., Orhan İ., Küsmenoǧlu Ş., Yeşilada E.

Turkish Journal of Pharmaceutical Sciences, cilt.4, sa.2, ss.89-99, 2007 (SCI-Expanded) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 4 Sayı: 2
  • Basım Tarihi: 2007
  • Dergi Adı: Turkish Journal of Pharmaceutical Sciences
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.89-99
  • Gazi Üniversitesi Adresli: Evet

Özet

Achillea species have been used for their anti-inflammatory, analgesic, spasmolytic, hemostatic, digestive and cholagogue effects in Turkish folk medicine. In order to evaluate their folkloric utilization, both antinociceptive and anti-inflammatory activities of five Achillea species including Achillea wilhelmsii C.Koch, A. setacea Waldst&Kit, A. vermicularis Trin., A. phrygia Boiss.&Bal. and A. sipikorensis Hausskn. et Borm. were investigated. For the antinociceptive activity, p-benzoquinoneinduced writhing test and for the anti-inflammatory activity, carrageenan-induced hind paw edema model in mice were employed. The ethanol extracts of A. wilhelmsii, A. setacea and A. vermicularis showed significant antinociceptive and anti-inflammatory activity at 500 mg/kg dose, per os, without inducing any apparent acute toxicity as well as gastric damage. A. phrygia was shown to possess only significant antinociceptive activity, on the other hand A. sipikorensis did not show any remarkable anti-inflammatory and antinociceptive activity.