Datura metel: A Review on Chemical Constituents, Traditional Uses and Pharmacological Activities


Alam W., Khan H., Khan S. A. , Nazir S., AKKOL E.

CURRENT PHARMACEUTICAL DESIGN, vol.27, no.22, pp.2545-2557, 2021 (Journal Indexed in SCI) identifier identifier

  • Publication Type: Article / Review
  • Volume: 27 Issue: 22
  • Publication Date: 2021
  • Doi Number: 10.2174/1381612826666200519113752
  • Title of Journal : CURRENT PHARMACEUTICAL DESIGN
  • Page Numbers: pp.2545-2557
  • Keywords: Datura metel, Solanaceae, phytochemistry, traditional uses, pharmacology, flavonoids, NITRIC-OXIDE, OXIDATIVE STRESS, ANTIINFLAMMATORY ACTIVITY, ANTIOXIDANT ACTIVITY, CRUDE EXTRACTS, FREE-RADICALS, LEAVES, FLOWER, WITHANOLIDES, FRUITS

Abstract

Datura metel (Solanaceae) which is commonly known as thorn's apple, Indian apple or devil's trumpet isan annual herb of temperate zones which is distributed all over the world. D. metel belongs to the family solanaceae. From a longer period of time (37 A.D), species of this family had therapeutic uses. This article is based on the review of different scientific backgrounds and studies regarding the traditional uses, phytochemistry, biochemical constituents and pharmacological uses of D. metel. This review is based on the facts of the available literature review. Different researchers conducted researches and studies on D. metel and confirmed the presence of enormous chemical compounds like flavonoids, tropane alkaloids, tannins, saponins and withanolides. D. metel has been found to be pharmacologically important species because of its different pharmacological and traditional uses, such as hepatoprotective, antiviral effect, antibacterial effect, anti-asthmatic, analgesic, antipyretic and nephroprotective effect, anticancer and antifungal effect. However, further in vivo and in vitro advanced studies are required to carried out for the exact pharmacological mechanisms and for basis of clinical utility.