The blood-brain barrier and beyond: Nano-based neuropharmacology and the role of extracellular matrix


Henrich-Noack P., Nikitovic D., Neagu M., Docea A. O. , ENGİN A. B. , Gelperina S., ...More

NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE, vol.17, pp.359-379, 2019 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 17
  • Publication Date: 2019
  • Doi Number: 10.1016/j.nano.2019.01.016
  • Journal Name: NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.359-379
  • Keywords: Brain pathology, Nanomedicine, Neuropharmacology, Blood brain bather, Extracellular matrix, AMYOTROPHIC-LATERAL-SCLEROSIS, CENTRAL-NERVOUS-SYSTEM, POLYCYCLIC AROMATIC-HYDROCARBONS, ASSEMBLING PEPTIDE NANOFIBER, CEREBRAL-ARTERY OCCLUSION, SPINAL-CORD-INJURY, DRUG-DELIVERY, IN-VITRO, PARKINSONS-DISEASE, PERINEURONAL NETS
  • Gazi University Affiliated: Yes

Abstract

Restrained drug delivery due to the blood-brain barrier (BBB) considerably limits options for the treatment of brain pathologies. The utilization of nanoparticulate (NP) carriers has been proposed as a solution. The development strategies need to address the important hurdle of NP passage across the BBB as well as the altered cellular up-take due to the pathophysiological changes of the damaged or diseased tissue as well as immunological and toxicological aspects of nanomedicine penetration. This review therefore scopes to: 1) outline the state-of-the art knowledge on BBB passage, 2) address the significant influence of pathological conditions on nanoparticulate drug delivery, and, 3) highlight the largely neglected role of the extracellular matrix (ECM). Interactions of the nanosystem with biological barriers, cells and ECM in the milieu of brain pathologies are critically discussed in order to present a holistic overview of the advances and pits of nanomedicine applications in brain disease. (C) 2019 Elsevier Inc. All rights reserved.