Beige Adipocyte as the Flame of White Adipose Tissue: Regulation of Browning and Impact of Obesity

Altinova A.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, vol.107, no.5, 2022 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Review
  • Volume: 107 Issue: 5
  • Publication Date: 2022
  • Doi Number: 10.1210/clinem/dgab921
  • Journal Name: JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, PASCAL, BIOSIS, CAB Abstracts, Chemical Abstracts Core, CINAHL, EMBASE, Food Science & Technology Abstracts, Gender Studies Database, MEDLINE, Veterinary Science Database
  • Keywords: beige, beiging, browning, brown adipose tissue, obesity, thermogenesis, MESSENGER-RNA EXPRESSION, MORPHOGENETIC PROTEIN 4, MITOCHONDRIAL BIOGENESIS, CALORIC RESTRICTION, ENERGY-EXPENDITURE, UCP-1 EXPRESSION, GENE-EXPRESSION, BONE-MARROW, WEIGHT-LOSS, FAT
  • Gazi University Affiliated: Yes

Abstract

Beige adipocyte, the third and relatively new type of adipocyte, can emerge in white adipose tissue (WAT) under thermogenic stimulations that is termed as browning of WAT. Recent studies suggest that browning of WAT deserves more attention and therapies targeting browning of WAT can be helpful for reducing obesity. Beyond the major inducers of browning, namely cold and beta (3)-adrenergic stimulation, beige adipocytes are affected by several factors, and excess adiposity per se may also influence the browning process. The objective of the present review is to provide an overview of recent clinical and preclinical studies on the hormonal and nonhormonal factors that affect the browning of WAT. This review further focuses on the role of obesity per se on browning process.