Cyclooxygenase-2 expression and its association with angiogenesis, Helicobacter pylori, and clinicopathologic characteristics of gastric carcinoma

Yamac, Deniz; Ayyildiz, Talat; Coskun, UĞUR; AKYÜREK, NALAN; DURSUN, AYŞE; Seckin, Selda; Koybasioglu, Fulya

doi:10.1016/j.prp.2008.01.002

Cyclooxygenase-2 expression and its association with angiogenesis, Helicobacter pylori, and clinicopathologic characteristics of gastric carcinoma

Yamac D., Ayyildiz T., Coskun U., AKYÜREK N., DURSUN A., Seckin S., ...Daha Fazla

PATHOLOGY RESEARCH AND PRACTICE, cilt.204, sa.8, ss.527-536, 2008 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 204 Sayı: 8
Basım Tarihi: 2008
Doi Numarası: 10.1016/j.prp.2008.01.002
Dergi Adı: PATHOLOGY RESEARCH AND PRACTICE
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.527-536
Anahtar Kelimeler: COX-2, angiogenesis, CD31, H.-pylori, gastric cancer, ENDOTHELIAL GROWTH-FACTOR, NITRIC-OXIDE SYNTHASE, TUMOR ANGIOGENESIS, GENE-EXPRESSION, UP-REGULATION, ASPIRIN USE, CANCER, OVEREXPRESSION, INFECTION, STOMACH
Gazi Üniversitesi Adresli: Evet

Özet

Cyclooxygenase-2 (COX-2) is upregulated in gastric carcinoma, and its increased levels were found to have a prognostic significance in some studies. Both angiogenesis and Helicobacter pylori infection have been reported to be associated with COX-2 expression of gastric cancer in recent studies.