The impact of reconstruction and scanner characterisation on the diagnostic capability of a normal database for [I-123]FP-CIT SPECT imaging

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Dickson J. C., Tossici-Bolt L., Sera T., Booij J., Ziebell M., Morbelli S., ...More

EJNMMI RESEARCH, vol.7, 2017 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 7
  • Publication Date: 2017
  • Doi Number: 10.1186/s13550-016-0253-0
  • Journal Name: EJNMMI RESEARCH
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Keywords: [I-123]FP-CIT, SPECT, Quantification, Reconstruction, Dopamine transporter, HEALTHY CONTROLS, BINDING RATIO, TOMOGRAPHY, DISEASE, IMAGES
  • Gazi University Affiliated: Yes

Abstract

Background: The use of a normal database for [I-123]FP-CIT SPECT imaging has been found to be helpful for cases which are difficult to interpret by visual assessment alone, and to improve reproducibility in scan interpretation. The aim of this study was to assess whether the use of different tomographic reconstructions affects the performance of a normal [I-123] FP-CIT SPECT database and also whether systems benefit from a system characterisation before a database is used.