Synthesis of new 2-[1(2H)-phthalazinon-2-yl]-acetamide and 3-[1(2H)-phthalazinon-2-yl]-propanamide derivatives as antinociceptive and anti-inflammatory agents

DOĞRUER D. S., Kupeli E., Yesilada E., Sahin M.

ARCHIV DER PHARMAZIE, vol.337, no.6, pp.303-310, 2004 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 337 Issue: 6
  • Publication Date: 2004
  • Doi Number: 10.1002/ardp.200200719
  • Journal Name: ARCHIV DER PHARMAZIE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.303-310
  • Keywords: 1(2H), phthalazinone, antinociceptive, anti-inflammatory, 3(2H)-PYRIDAZINONE DERIVATIVES
  • Gazi University Affiliated: Yes

Abstract

As a consequence of our ongoing studies on heterocyclic compounds for new antinociceptive and anti-inflammatory agents bearing lactam functional group, new 2-[1(2H)-phthalazinon-2-yl]acetamide and 3-[1(2H)-phthalazinon-2-yl]propanamide derivatives have been synthesized. Among the compounds synthesized, compound 4e was found the most active derivative in terms of antinociceptive and anti-inflammatory activities, without gastric lesions and bleeding at the given dose.