Synthesis of new 2-[1(2H)-phthalazinon-2-yl]-acetamide and 3-[1(2H)-phthalazinon-2-yl]-propanamide derivatives as antinociceptive and anti-inflammatory agents

DOĞRUER, DENİZ; Kupeli, E; Yesilada, E; Sahin, MF

doi:10.1002/ardp.200200719

Synthesis of new 2-[1(2H)-phthalazinon-2-yl]-acetamide and 3-[1(2H)-phthalazinon-2-yl]-propanamide derivatives as antinociceptive and anti-inflammatory agents

DOĞRUER D. S., Kupeli E., Yesilada E., Sahin M.

ARCHIV DER PHARMAZIE, cilt.337, sa.6, ss.303-310, 2004 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 337 Sayı: 6
Basım Tarihi: 2004
Doi Numarası: 10.1002/ardp.200200719
Dergi Adı: ARCHIV DER PHARMAZIE
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.303-310
Anahtar Kelimeler: 1(2H), phthalazinone, antinociceptive, anti-inflammatory, 3(2H)-PYRIDAZINONE DERIVATIVES
Gazi Üniversitesi Adresli: Evet

Özet

As a consequence of our ongoing studies on heterocyclic compounds for new antinociceptive and anti-inflammatory agents bearing lactam functional group, new 2-[1(2H)-phthalazinon-2-yl]acetamide and 3-[1(2H)-phthalazinon-2-yl]propanamide derivatives have been synthesized. Among the compounds synthesized, compound 4e was found the most active derivative in terms of antinociceptive and anti-inflammatory activities, without gastric lesions and bleeding at the given dose.