Effects of vitamin A and C and melatonin on 3-nitrotyrosine formation in guinea pig heart under lipopolysaccharide-induced stress

Yaman H., Cayci T., Seyrek M., Akgul E. O., Kurt Y. G., Aydin I., ...More

TURKISH JOURNAL OF MEDICAL SCIENCES, vol.40, no.5, pp.715-721, 2010 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 40 Issue: 5
  • Publication Date: 2010
  • Doi Number: 10.3906/sag-0906-71
  • Journal Name: TURKISH JOURNAL OF MEDICAL SCIENCES
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.715-721
  • Gazi University Affiliated: Yes

Abstract

Aim: Bacterial lipopolysaccharide (LPS) triggers synthesis of nitric oxide (NO) and superoxide (O(2)(-)).O(2)(-) can react with NO to produce the powerful oxidant peroxynitrite (ONOO(-)). The presence of 3-nitrotyrosine (3-NT) in tissues is often used as a marker of ONOO(-) production. Vitamin A, vitamin C, and melatonin are potent antioxidant molecules. We sought to clarify this issue by examining the effects of vitamin A (15,000 IU/kg/day), vitamin C (600 mg/kg/day), and melatonin (25 mg/kg) on 3-NT formation in heart tissue in a guinea pig model of LPS-induced endotoxemia.