Antithrombin III prevents deleterious effects of remote ischemia-reperfusion injury on healing of colonic anastomoses


Tekin K., Aytekin F., Ozden A., Bilgihan A., Erdem E., Sungurtekin U., ...Daha Fazla

AMERICAN JOURNAL OF SURGERY, cilt.184, sa.2, ss.160-165, 2002 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 184 Konu: 2
  • Basım Tarihi: 2002
  • Doi Numarası: 10.1016/s0002-9610(02)00908-x
  • Dergi Adı: AMERICAN JOURNAL OF SURGERY
  • Sayfa Sayıları: ss.160-165

Özet

Background: Antithrombin III is known as the most important natural inhibitor of thrombin activity and has been shown to attenuate local harmful effects of ischemia-reperfusion injury in many organs. In recent animal studies, delaying effect of remote organ ischemia-reperfusion injury on healing of intestinal anastomoses has been demonstrated. In this study, we investigated whether antithrombin III reduces deleterious systemic effects of ischemia-reperfusion injury on healing of colonic anastomoses in rats.