Antithrombin III prevents deleterious effects of remote ischemia-reperfusion injury on healing of colonic anastomoses
AMERICAN JOURNAL OF SURGERY, cilt.184, sa.2, ss.160-165, 2002 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 184 Sayı: 2
- Basım Tarihi: 2002
- Doi Numarası: 10.1016/s0002-9610(02)00908-x
- Dergi Adı: AMERICAN JOURNAL OF SURGERY
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.160-165
- Gazi Üniversitesi Adresli: Evet
Özet
Background: Antithrombin III is known as the most important natural inhibitor of thrombin activity and has been shown to attenuate local harmful effects of ischemia-reperfusion injury in many organs. In recent animal studies, delaying effect of remote organ ischemia-reperfusion injury on healing of intestinal anastomoses has been demonstrated. In this study, we investigated whether antithrombin III reduces deleterious systemic effects of ischemia-reperfusion injury on healing of colonic anastomoses in rats.