The effect of smoking on epithelial proliferation in healthy and periodontally diseased marginal gingival epithelium

GÜLTEKİN S. E., Sengueven B., Karaduman B.

JOURNAL OF PERIODONTOLOGY, vol.79, no.8, pp.1444-1450, 2008 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 79 Issue: 8
  • Publication Date: 2008
  • Doi Number: 10.1902/jop.2008.070645
  • Journal Name: JOURNAL OF PERIODONTOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1444-1450
  • Keywords: cell proliferation, epithelium, gingiva, smoking, CELL NUCLEAR ANTIGEN, KI-67 PROTEIN, MONOCLONAL-ANTIBODY, CIGARETTE-SMOKING, PARAFFIN SECTIONS, PROGNOSTIC VALUE, RISK FACTOR, EXPRESSION, TOBACCO, CARCINOMA
  • Gazi University Affiliated: Yes

Abstract

Background: Smoking causes an increase in the thickness of gingival epithelium, which is the outcome of increased keratinocyte proliferation or loss. Smoking-related changes in the proliferative activity of the gingival epithelium are largely uncharacterized for periodontal diseases. The aim of the present study was to determine the effects of smoking on the proliferation of the epithelium in periodontally diseased marginal gingiva by comparing the expression patterns of two different proliferation markers.