The aim of the study was to investigate phyto chemical compoundsof fig leaves and antimicrobial activity of different extracts. The extract of ethanol, methanol, aqueous fig leaves (Ficus carica L.) were screened in vitro for their antimicrobial activity against Gram-positive, Gram-negative bacteria and one yeast.. Ethanolic extracts of fig leaves showed various antimicrobial activity (12-28 20 mu L-1 inhibition zone) to the microorganisms tested. The methanolic extracts showed antimicrobial activity (9-15 20 mu L-1 inhibition zone) to the microorganisms tested. The aqueous extracts showed no inhibition zone three out of ten microorganisms. The ethanolic extract displayed the best activity (MIC 6.25 mu g/mL) against Bacillus cereus CCM 99. Other microorganisms (Escherichia coli ATCC 35218, Salmonella typhimurium CCM 583, P aeruginosa ATCC 27853, Bacillus subtilis ATCC 6633) were showed between MIC 6.25-200 mu g/mL. The methanolic and aqueous extracts were between MIC 25-400< mu g/mL and MIC 200-400< mu g/mL, respectively. The GC/MS analyses allowed 11 compounds to be determined; the main constituents of the fig leaves extract were etanol (94.36%), 6-methylthiol(1)benzothienoquinoline (0.94%) and methyl benzoylformate (0.84%).