Topical Cyclosporine in Thyroid Orbitopathy-Related Dry Eye: Clinical Findings, Conjunctival Epithelial Apoptosis, and MMP-9 Expression


Gurdal C., Genc I., SARAÇ Ö., IŞIK GÖNÜL İ. , Takmaz T., Can I.

CURRENT EYE RESEARCH, vol.35, no.9, pp.771-777, 2010 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 35 Issue: 9
  • Publication Date: 2010
  • Doi Number: 10.3109/02713683.2010.490320
  • Title of Journal : CURRENT EYE RESEARCH
  • Page Numbers: pp.771-777
  • Keywords: Dry Eye, Thyroid Ophthalmopathy, Cyclosporine A, Apoptosis, MMP-9, TEAR FILM OSMOLARITY, OCULAR SURFACE, KERATOCONJUNCTIVITIS SICCA, PERMEABILITY TRANSITION, INFLAMMATORY CYTOKINES, DISEASE, OPHTHALMOPATHY, MATRIX-METALLOPROTEINASE-9, DISRUPTION, MARKERS

Abstract

Objectives: To evaluate the effects of topical cyclosporine A (CsA) 0.05% (Restasis) on the signs and symptoms of dry eye, on apoptosis, and on MMP-9 expression in conjunctiva epithelial cells in thyroid orbitopathy (TO)-related dry eye patients.