Topical Cyclosporine in Thyroid Orbitopathy-Related Dry Eye: Clinical Findings, Conjunctival Epithelial Apoptosis, and MMP-9 Expression

Gurdal C., Genc I., SARAÇ Ö., IŞIK GÖNÜL İ., Takmaz T., Can I.

CURRENT EYE RESEARCH, cilt.35, sa.9, ss.771-777, 2010 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 35 Sayı: 9
  • Basım Tarihi: 2010
  • Doi Numarası: 10.3109/02713683.2010.490320
  • Dergi Adı: CURRENT EYE RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.771-777
  • Anahtar Kelimeler: Dry Eye, Thyroid Ophthalmopathy, Cyclosporine A, Apoptosis, MMP-9, TEAR FILM OSMOLARITY, OCULAR SURFACE, KERATOCONJUNCTIVITIS SICCA, PERMEABILITY TRANSITION, INFLAMMATORY CYTOKINES, DISEASE, OPHTHALMOPATHY, MATRIX-METALLOPROTEINASE-9, DISRUPTION, MARKERS
  • Gazi Üniversitesi Adresli: Evet

Özet

Objectives: To evaluate the effects of topical cyclosporine A (CsA) 0.05% (Restasis) on the signs and symptoms of dry eye, on apoptosis, and on MMP-9 expression in conjunctiva epithelial cells in thyroid orbitopathy (TO)-related dry eye patients.