Anesthetic agents modulate on oxidant/antioxidant activity. This study aimed to evaluate the effects of desflurane and sevoflurane anesthesia on the oxidant/antioxidant activity in the liver of young and aged rats. The study involved 60 male Wistar Albino Rats. Rats, which 5-6 months of age deemed as young (Group Y, n = 30) and 10-11 months of age deemed as old (Group O, n = 30). The weight range of the rats was 270-350 g. The groups of rats were randomly divided into 3 groups as the control group [Group Y, (Young Control 100% O-2; n = 10) and Group O-c (Old Control 100% 0,; n = 10)], desflurane group [Group Y-D, (Young Desflurane; 6% Desflurane in 100% O-2; n = 10)] and Group O-2, (Old Desfluranee; 6% Desflurane in 100% O-2; n = 10)] and sevoflurane group [Group Y-S (Young Sevoflurane; 2% Sevoflurane in 100% O-2; n = 10) and Group O-S (Old Sevoflurane; 2% Sevoflurane in 100% 02; n = 10)]. The rats placed into a transparent plastic cage. The rats were exposed to different anesthetic agents or oxygen for 2 h by the use of half open Anesthesia System (AMS, Senior 425), while rats' simultaneous normal breathing was maintained. At the end of the exposure, they were administered a high dose of ketamine and the livers of the animals were sugically removed. SOD, GST and NOS activities were determined and levels of oxidative stress was monitored by measuring TBARS via levels of MDA in the liver. Desflurane induce oxidative stress in both young and old rats, with higher levels in old rats. However, sevoflurane did not cause oxidative stress in young rats. Sevoflurane increased the oxidative stress in the old rats based on SOD and TBARS levels, while it maintained GST activity and decreased NOS activity. However, further studies are needed.