Can Sevoflurane Induce Micronuclei Formation in Nasal Epithelial Cells of Adult Patients?

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Kesimci E., Coskun E., Ugur G., Muderris T., İZDEŞ S., KARAHALİL B.

TURKISH JOURNAL OF ANAESTHESIOLOGY AND REANIMATION, cilt.45, sa.5, ss.264-269, 2017 (ESCI) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 45 Sayı: 5
  • Basım Tarihi: 2017
  • Doi Numarası: 10.5152/tjar.2017.09475
  • Dergi Adı: TURKISH JOURNAL OF ANAESTHESIOLOGY AND REANIMATION
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.264-269
  • Anahtar Kelimeler: Volatile anaesthetics, sevoflurane, mask induction, genotoxicity, nasal epithelium, SISTER-CHROMATID EXCHANGES, COMET ASSAY, HUMAN-LYMPHOCYTES, DNA-DAMAGE, THEATER PERSONNEL, ANESTHESIA, GENOTOXICITY, CYTOTOXICITY, ISOFLURANE, EXPOSURE
  • Gazi Üniversitesi Adresli: Evet

Özet

Objective: Volatile anaesthetics can inhibit the bronchociliary clearence in a dose-and time-dependend way. Moreover, they can have potential mutagenic/carcinogenic effects under chronic exposure. A genotoxicity test-micronuclei assay-was carried out in nasal epithelial cells to analyze the genotoxic effect of sevoflurane in adult patients undergoing general anesthesia.