Synthesis, Characterization and X-Ray Crystal Structure of the New Schiff Base and Anticandidal Evaluation

POYRAZ M., SARI M., BERBER H., Karaca N., DEMİRCİ F.

JOURNAL OF THE CHEMICAL SOCIETY OF PAKISTAN, cilt.41, sa.6, ss.1090-1096, 2019 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 41 Sayı: 6
  • Basım Tarihi: 2019
  • Dergi Adı: JOURNAL OF THE CHEMICAL SOCIETY OF PAKISTAN
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1090-1096
  • Anahtar Kelimeler: Schiff base, Crystal structure, Methoxy, Human pathogenic, Anticandidal activity, MACROCYCLIC LIGAND DESIGN, BIOLOGICAL-ACTIVITY, MANNICH-BASES, COMPLEXES, COPPER(II), SALICYLALDEHYDE, CONDENSATION, DERIVATIVES, NICKEL(II), TRANSITION
  • Gazi Üniversitesi Adresli: Evet

Özet

A new Schiff base, namely 2-methoxy-6-((2-(4 nitrophenyl) hydrazineylidene) methyl)phenol was synthesized and characterized by melting points, elemental analysis, thermogravimetric analysis and spectroscopic techniques (FT-IR, H-1-NMR and UV-VIS spectra). The chemical structure of compound was further confirmed by single crystal structural X-ray diffraction. The Schiff base is crystallized in the triclinic space group P-1. In the crystal, molecules are linked by O-H center dot center dot center dot O hydrogen bonds between the hydroxy "-O-" atom and the methoxy "-O-" atom. Furthermore, the synthesized Schiff base was tested for the in vitro anticandidal activities using CLSI broth microdilution method against human pathogenic Candida albicans, C. parapsilosis and C. krusei standard strains. In the anticandidal activity test results, the new Schiff base was found to be effective at 1 mg/mL - 0.25 mg/mL concentrations.