Background and objectives: A key aspect of cisplatin-induced hepatotoxicity is oxidative stress. The current study was conducted to show, for the first time, the restoring and synergistic effects of morin and hesperidin against oxidative stress in hepatotoxicity. Methods: Fourty-two Wistar albino rats were randomly divided into seven groups: group A (control), group B (morin), group C (hesperidin), group D (cisplatin), group E (cisplatin+morin), group F (cisplatin+hesperidin), group G (cisplatin+morin+hesperidin). Throughout ten consecutive days, morin and/or hesperidin were given to rats and cisplatin was injected as a single dose (7 mg/kg) on the 4th day, and then the rats were sacrificed on the 11th day. Liver tissue samples collected from the rats were used for the measurement of malondialdehyde, nitric oxide, glutathione levels as well as myeloperoxidase, catalase and superoxide dismutase activities. Results: Administration of cisplatin elevated the malondialdehyde and nitric oxide levels and also reduced the glutathione levels and catalase activity in the liver. However, in the morin and/or hesperidin groups, glutathione level and catalase activity were higher but malondialdehyde and nitric oxide levels and myeloperoxidase activity were lower than the cisplatin-induced group. Conclusion: Our results indicated that pretreatment with these flavonoids can be used as protective treatment for cisplatin-induced hepatotoxicity.