Leukocyte Telomere Length and Its Association with Serum Silent Information Regulator-1, Body Composition, Glycemic Control, and Diabetic Complications in Type 2 Diabetes Mellitus

ÜNVER N. G., ALTINOVA A. E., COŞKUN M., AKTÜRK M., YALÇIN M. M., TÖRÜNER F. S., ...Daha Fazla

ENDOCRINOLOGY RESEARCH AND PRACTICE, cilt.27, sa.3, ss.148-153, 2023 (ESCI) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 27 Sayı: 3
  • Basım Tarihi: 2023
  • Doi Numarası: 10.5152/erp.2023.22199
  • Dergi Adı: ENDOCRINOLOGY RESEARCH AND PRACTICE
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.148-153
  • Anahtar Kelimeler: Bioelectrical impedance and obesity, Sirtuin-1, Telomere length, Type 2 diabetes mellitus
  • Gazi Üniversitesi Adresli: Evet

Özet

Objective: The aim of this study is to investigate the length of telomere and serum silent information regulator-1 levels in type 2 diabetic subjects as well as their associations with body composition, glycemic control, and diabetic complications. Methods: We enrolled 84 type 2 diabetic subjects and 40 controls. The length of telomere and serum silent information regulator-1 (Sir tuin-1) levels, body composition and diabetic complications were examined. Results: Median T/S ratio tended to be lower in type 2 diabetic subjects compared to the controls (1.03 (0.20-1.48) vs. 1.25 (0.80-1.69), P = .064); however, the percentage of having shorter telomere ( T/S ratio < 1) was significantly higher in type 2 diabetic subjects than in the controls (47.6% vs. 27.5%, P = .035). Serum Sir tuin-1 level was lower in type 2 diabetic subjects than in controls (95.48 & PLUSMN; 29.9 vs. 138.40 & PLUSMN; 42.66 pg/mL, P < .001). There were no differences in the length of telomere and serum sir tuin-1 between the groups divided according to the presence of diabetic complications (P > .05). The percentage of having shorter telomere was higher in obese patients than in non-obese patients with DM (35.7% vs. 60%, P = .029). The T/S ratio was correlated with truncal fat in type 2 diabetic subjects (r = -0.250, P = .028). Conclusions: The length of telomere and silent information regulator-1 may have a role in cellular aging in type 2 diabetic subjects in relation to visceral obesity.