Multiuser detection (MUD) and channel estimation techniques in space-division multiple-access aided orthogonal frequency-division multiplexing systems recently has received intensive interest in receiver design technologies. The maximum likelihood (ML) MUD that provides optimal performance has the cost of a dramatically increased computational complexity. The minimum mean-squared error (MMSE) MUD exhibits poor performance, although it achieves lower computational complexity. With almost the same complexity, an MMSE with successive interference cancellation (SIC) scheme achieves a better bit error rate performance than a linear MMSE multiuser detector. In this paper, hybrid ML-MMSE with SIC adaptive multiuser detection based on the joint channel estimation method is suggested for signal detection. The simulation results show that the proposed method achieves good performance close to the optimal ML performance at low SNR values and a low computational complexity at high SNR values.