Can urine osteopontin levels, which may be correlated with nutrition intake and body composition, be used as a new biomarker in the diagnosis of nephrolithiasis?

Icer M. A. , GEZMEN KARADAĞ M. , Sozen S.

CLINICAL BIOCHEMISTRY, vol.60, pp.38-43, 2018 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 60
  • Publication Date: 2018
  • Doi Number: 10.1016/j.clinbiochem.2018.08.001
  • Title of Journal : CLINICAL BIOCHEMISTRY
  • Page Numbers: pp.38-43
  • Keywords: Nephrolithiasis, Osteopontin, Biomarker, Dietary effects, Body composition, Creatinine, KIDNEY-STONES, CRYSTAL-FORMATION, ADIPOSE-TISSUE, RAT-KIDNEY, EXPRESSION, OBESITY, MANAGEMENT, INHIBITOR, HEALTHY, DISEASE


Background and aim: The nephrolithiasis has a multifactorial etiology resulting from the interaction of metabolic, genetic and environmental factors. Parameters such as nutrition and urinary osteopontin (OPN) level may affect kidney stone formation. The purpose of this study is to evaluate the correlation between urinary OPN level and kidney stone formation and effect of nutrition on OPN level in nephrolithiasis.