Evaluation of some plants used in Turkish folk medicine for their anti-inflammatory and antinociceptive activities

Kupeli E., Orhan İ. , Yesilada E.

PHARMACEUTICAL BIOLOGY, cilt.45, sa.7, ss.547-555, 2007 (SCI İndekslerine Giren Dergi) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 45 Konu: 7
  • Basım Tarihi: 2007
  • Doi Numarası: 10.1080/13880200701498895
  • Sayfa Sayıları: ss.547-555


Ethanol and aqueous extracts obtained from 11 plant species from 11 families selected based on their use in Turkish folk medicine, including Isatis glauca Aucher x Boiss. subsp glauca ( herb) ( Brassicaceae), Tamus communis L. ( herb and root) ( Dioscoreaceae), Rumex crispus L. ( herb) ( Polygonaceae), Daphne oleoides Schreber ( aerial parts) ( Thymeleaceae), Laurus nobilis L. ( leaves and seeds) ( Lauraceae), Ranunculus tricophyllus Chaix ( herb) ( Ranunculaceae), Anchusa azurea Miller var. azurea ( herb) ( Boraginaceae), Calluna vulgaris L. ( herb) ( Ericaceae), Prunella vulgaris L. ( herb) ( Lamiaceae), Scabiosa rotata Bieb. ( herb) ( Dipsacaceae), and Arceuthobium oxycedri ( DC.) Bieb. ( herb) ( Loranthaceae), were evaluated for their in vivo anti- inflammatory and antinociceptive activities. Among the plant extracts studied, the ethanol extracts of Laurus nobilis seed and Calluna vulgaris herb and the aqueous and ethanol extracts of Arceuthobium oxycedri herb displayed significant anti- inflammatory activity using carrageenan-induced hind paw edema model in mice without inducing any gastric damage. The ethanol extracts of Isatis glauca subsp. glauca, Calluna vulgaris, Laurus nobilis ( seeds) as well as the aqueous and ethanol extracts of Arceuthobium oxycedri were also shown to possess significant antinociceptive activity in varying degrees against p- benzoquinone-induced abdominal contraction test in mice.