Atıf İçin Kopyala
UTKU S., ÖZÇELİK A. B., Gumus F., Yilmaz S., Arsoy T., AÇIK L., ...Daha Fazla
JOURNAL OF PHARMACY AND PHARMACOLOGY, cilt.66, sa.11, ss.1593-1605, 2014 (SCI-Expanded)
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Yayın Türü:
Makale / Tam Makale
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Cilt numarası:
66
Sayı:
11
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Basım Tarihi:
2014
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Doi Numarası:
10.1111/jphp.12290
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Dergi Adı:
JOURNAL OF PHARMACY AND PHARMACOLOGY
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Derginin Tarandığı İndeksler:
Science Citation Index Expanded (SCI-EXPANDED), Scopus
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Sayfa Sayıları:
ss.1593-1605
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Anahtar Kelimeler:
benzimidazole, cytotoxic activity, DNA binding, gel electrophoresis, platinum(II) complexes, PLATINUM(II) COMPLEXES, PT(II) COMPLEXES, CANCER CELLS, CISPLATIN, EFFICACY, BINDING, MCF-7
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Gazi Üniversitesi Adresli:
Evet
Özet
ObjectivesThe aim of this study was to investigate the in-vitro cytotoxic activity of new platinum(II) complexes on the human HeLa (ER-), MCF-7 (ER+) and MDA-MB 231 (ER-) cell lines. Furthermore, we investigated plasmid DNA interactions and inhibition of BamHI and HindIII restriction enzyme activity of the complex 1-4,7.