Synthesis, in-vitro cytotoxic activity and DNA interactions of new dicarboxylatoplatinum(II) complexes with 2-hydroxymethylbenzimidazole as carrier ligands


UTKU S., ÖZÇELİK A. B. , Gumus F., Yilmaz S., Arsoy T., AÇIK L. , ...Daha Fazla

JOURNAL OF PHARMACY AND PHARMACOLOGY, cilt.66, sa.11, ss.1593-1605, 2014 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 66 Konu: 11
  • Basım Tarihi: 2014
  • Doi Numarası: 10.1111/jphp.12290
  • Dergi Adı: JOURNAL OF PHARMACY AND PHARMACOLOGY
  • Sayfa Sayıları: ss.1593-1605

Özet

ObjectivesThe aim of this study was to investigate the in-vitro cytotoxic activity of new platinum(II) complexes on the human HeLa (ER-), MCF-7 (ER+) and MDA-MB 231 (ER-) cell lines. Furthermore, we investigated plasmid DNA interactions and inhibition of BamHI and HindIII restriction enzyme activity of the complex 1-4,7.