Synthesis, in-vitro cytotoxic activity and DNA interactions of new dicarboxylatoplatinum(II) complexes with 2-hydroxymethylbenzimidazole as carrier ligands

UTKU, SEMRA; ÖZÇELİK, AZİME; Gumus, Fatma; Yilmaz, Sukran; Arsoy, Taibe; AÇIK, LEYLA; ÇELEBİ KESKİN, AYTEN

doi:10.1111/jphp.12290

Synthesis, in-vitro cytotoxic activity and DNA interactions of new dicarboxylatoplatinum(II) complexes with 2-hydroxymethylbenzimidazole as carrier ligands

UTKU S., ÖZÇELİK A. B., Gumus F., Yilmaz S., Arsoy T., AÇIK L., ...Daha Fazla

JOURNAL OF PHARMACY AND PHARMACOLOGY, cilt.66, sa.11, ss.1593-1605, 2014 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 66 Sayı: 11
Basım Tarihi: 2014
Doi Numarası: 10.1111/jphp.12290
Dergi Adı: JOURNAL OF PHARMACY AND PHARMACOLOGY
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.1593-1605
Anahtar Kelimeler: benzimidazole, cytotoxic activity, DNA binding, gel electrophoresis, platinum(II) complexes, PLATINUM(II) COMPLEXES, PT(II) COMPLEXES, CANCER CELLS, CISPLATIN, EFFICACY, BINDING, MCF-7
Gazi Üniversitesi Adresli: Evet

Özet

ObjectivesThe aim of this study was to investigate the in-vitro cytotoxic activity of new platinum(II) complexes on the human HeLa (ER-), MCF-7 (ER+) and MDA-MB 231 (ER-) cell lines. Furthermore, we investigated plasmid DNA interactions and inhibition of BamHI and HindIII restriction enzyme activity of the complex 1-4,7.