Protective potential of curcumin or taurine on nephrotoxicity caused by bisphenol A

ASLANTÜRK A., UZUNHİSARCIKLI M.

ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH, cilt.27, sa.19, ss.23994-24003, 2020 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 27 Sayı: 19
  • Basım Tarihi: 2020
  • Doi Numarası: 10.1007/s11356-020-08716-1
  • Dergi Adı: ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, IBZ Online, ABI/INFORM, Aerospace Database, Agricultural & Environmental Science Database, Aqualine, Aquatic Science & Fisheries Abstracts (ASFA), BIOSIS, CAB Abstracts, EMBASE, Environment Index, Geobase, MEDLINE, Pollution Abstracts, Veterinary Science Database, Civil Engineering Abstracts
  • Sayfa Sayıları: ss.23994-24003
  • Anahtar Kelimeler: BPA, Curcumin, Histopathology, Kidney, Oxidative stress, Taurine, OXIDATIVE STRESS, DNA-DAMAGE, HUMAN HEALTH, VITAMIN-C, MALE RATS, TOXICITY, LIVER, OCTYLPHENOL, KIDNEY, SPERM
  • Gazi Üniversitesi Adresli: Evet

Özet

Bisphenol A (BPA) received heightened attention in the recent years due to humans continuously being exposed to it. This study explores the effect of taurine or curcumin on subacute BPA treatment-induced nephrotoxicity in rats (Rattus norvegicus). Forty-two adult albino male rats were exposed to BPA (130 mg/kg daily) for 28 days by gastric gavage. BPA led to lipid peroxidation, inhibiting antioxidant enzyme activities like catalase (CAT), superoxide dismutase (SOD), glutathione peroxidase (GPx), and glutathione S-transferase (GST). BPA exposure also induced histopathological changes like tubular and glomerular degeneration, vascular congestion, and interstitial cell infiltration in kidney tissue. Cotreatment with taurine (100 mg/kg daily) or curcumin (100 mg/kg daily) alleviated the lipid peroxidation level and antioxidant enzyme activities and histological alterations brought about by BPA. In this study, curcumin and taurine application provided protection against renal toxicity caused by BPA but did not prevent toxic effect completely.