Effects of recurrent sevoflurane anesthesia on cognitive functions with streptozotocin induced Alzheimer disease

Creative Commons License

Erkent F. D., Isik B., Kucuk A., Ozturk L., Neselioglu S., Dogan H. T., ...Daha Fazla

Bratislava Medical Journal, cilt.120, sa.12, ss.887-893, 2019 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 120 Sayı: 12
  • Basım Tarihi: 2019
  • Doi Numarası: 10.4149/bll_2019_149
  • Dergi Adı: Bratislava Medical Journal
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.887-893
  • Anahtar Kelimeler: Alzheimer, sevoflurane, Radial Arm Maze Test, rat, GFAP, Caspase-3, DYNAMIC THIOL/DISULPHIDE HOMEOSTASIS, DYSFUNCTION, MEMORY, SURGERY, PHOSPHORYLATION, OLIGOMERIZATION, ISOFLURANE, APOPTOSIS, EXPOSURE, PLASMA
  • Gazi Üniversitesi Adresli: Evet

Özet

© 2019 Comenius University.OBJECTIVE: We aimed to investigate the effects of recurrent sevoflurane anesthesia on cognitive functions in Alzheimer Disease. MATERIALS AND METHODS: Rats were divided into 4 groups as followed: control (Group C), sevoflurane (Group S), Alzheimer's (Group A) and Alzheimer's + sevoflurane (Group AS)]. Cognitive functions were evaluated with Radial Arm Maze Test (RAMT). Alzheimer model was created by administering 3 mg/kg (10 μl) STZ. Sevoflurane was administered to S and AS groups. Serum samples and hippocampus tissues were analyzed. RESULTS: In RAM test, the entry-exit data were significantly decreased in A and AS groups. After the 2nd and 3rd administration of anesthesia, the numbers were significantly decreased in Group S. Glial-fibrillaryacidic protein levels were significantly higher in AS compared to the C and S groups. The brain tissue caspase 3 activity was less than 1% in all rats in the Group C, 3 % in 2 rats and 1 % in 1 rat in the Group AS. In A and AS group, serum catalase, myeloperoxidase and ferroxidase activities were found to be higher than in the other groups and myeloperoxidase activity was higher in the AS than in the A Group. Serum native thiol, total thiol and disulfi de levels were found to be significantly different in the A and AS groups. CONCLUSION: Sevoflurane anesthesia negatively affected the cognitive functions (Tab. 5, Fig. 10, Ref. 51). Text in PDF www.elis.sk.