Investigation of interleukin-1 alpha and interleukin-6 expression and interleukin-1 alpha gene polymorphism in keratocystic odontogenic tumors and ameloblastomas


Senguven B., Oygur T.

MEDICINA ORAL PATOLOGIA ORAL Y CIRUGIA BUCAL, vol.16, no.4, 2011 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 16 Issue: 4
  • Publication Date: 2011
  • Doi Number: 10.4317/medoral.16.e467
  • Title of Journal : MEDICINA ORAL PATOLOGIA ORAL Y CIRUGIA BUCAL
  • Keywords: Ameloblastoma, odontogenic keratocyst, keratocystic odontogenic tumor, interleukin, single nucleotide polymorphism, OSTEOCLAST FORMATION, PERIODONTAL-DISEASE, BONE-RESORPTION, TOOTH ERUPTION, INVASIVENESS, MANAGEMENT, PROTEIN

Abstract

Objective: In jawbones, ameloblastomas and odontogenic keratocysts share many clinical features in common such as aggressiveness, high recurrence rates and radical management options. Understanding the pathogenesis and biological aspects of these tumors would improve the success of diagnose and treatment procedures. The aim of this study was to exhibit the reasons of high recurrence rates and growth potentials of ameloblastomas and keratocystic odontogenic tumours by investigating the expression of IL-1 alpha and IL-6 and IL-1 alpha -889 gene polymorphism. IL-1 alpha and IL-6 are shown as very effective tissue degrading factors in bone remodelling.