Insulin-like growth factor-I and insulin-like growth factor binding protein-3 levels of children living in an iodine- and selenium-deficient endemic goiter area

Aydin K., Bideci A., Kendirci M., Cinaz P., Kurtoglu S.

BIOLOGICAL TRACE ELEMENT RESEARCH, cilt.90, ss.25-30, 2002 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 90
  • Basım Tarihi: 2002
  • Doi Numarası: 10.1385/bter:90:1-3:25
  • Dergi Adı: BIOLOGICAL TRACE ELEMENT RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.25-30
  • Anahtar Kelimeler: children, endemic goiter, iodine deficiency, selenium deficiency, insulin-like growth factor-I, insulin-like growth factor binding, protein-3, SERUM LEVELS, IGF-I, AGE, HYPERTHYROIDISM, HYPOTHYROIDISM
  • Gazi Üniversitesi Adresli: Evet

Özet

Serum insulin-like growth factor-I (IGF-I) and insulin-like growth factor binding protein-3 (IGFBP-3) levels were investigated in 31 children living in an endemic goiter area and 33 healthy subjects living in an nonendemic area. Serum lGF-I and IGFBP-3 levels of iodine- and selenium deficient children were found to be lower than those of control subjects (p<0.001). There was a positive correlation between the IGF-I with chronological age and body mass index. There was also positive correlation between the lGF-I and IGFBP-3. No significant difference was found between the goitrous and nongoitrous children. These results suggest that IGF-I and IGFBP-3 levels are affected by thyroid dysfunction as a result of iodine and selenium deficiency. However, IGF-I and IGFBP-3 levels are not associated with goiter.