Synthesis and antinociceptive activity of 2-[(2-oxobenzothiazolin-3-yl) methyl]-5-aminoalkyl/aryl-1,3,4-thiadiazole

Onkol T., Cakir B., Sahin M., Yildirim E., Erol K.

TURKISH JOURNAL OF CHEMISTRY, cilt.28, sa.4, ss.461-468, 2004 (SCI-Expanded) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 28 Sayı: 4
  • Basım Tarihi: 2004
  • Dergi Adı: TURKISH JOURNAL OF CHEMISTRY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.461-468
  • Anahtar Kelimeler: 2-oxobelizothiazoline, 1,3,4-thiadiazole, antinociceptive activity, 2(3H)-BENZOTHIAZOLONE DERIVATIVES, ANTIINFLAMMATORY ACTIVITY, ANTIMICROBIAL ACTIVITY, BIOLOGICAL EVALUATION, AGENTS, 1,3,4-THIADIAZOLE, 2(3H)-BENZOXAZOLONE, THIOSEMICARBAZIDE, 1,2,4-TRIAZOLE, INDOLE
  • Gazi Üniversitesi Adresli: Hayır

Özet

Ten 2-[(2-oxobenzothiazolin-3-yl)methyl]-5-aminoalkyl/aryl-1,3,4-thiadiazole derivatives were synthesized. The chemical structures of these compounds were elucidated by their FT-IR and H-1-NMR spectral data, as well as their elemental analyses. The compounds were tested for antinociceptive activity. Among these compounds, 2-[(2-oxobenzothiazolin-3-yl)methyl]-5-aminomethyl-1,3,4-thiadiazole (5a) was found to be significantly more active than the others and the standards in all the tests.