EFFECTS OF MELOXICAM, ALONE AND IN COMBINATION WITH CHEMOTHERAPEUTIC AGENTS ON THE RAF/MEK/ERK PATHWAY IN RAJI CELLS

ÖNEN H. İ., Yilmaz A., Alp E., YAR SAĞLAM A. S., KONAÇ E., Menevse S.

ACTA MEDICA MEDITERRANEA, cilt.30, sa.3, ss.717-723, 2014 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 30 Sayı: 3
  • Basım Tarihi: 2014
  • Dergi Adı: ACTA MEDICA MEDITERRANEA
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.717-723
  • Anahtar Kelimeler: Meloxicam, gemcitabine, raji cell line, gene expression, burkitt lenfoma, NONSTEROIDAL ANTIINFLAMMATORY DRUGS, SELECTIVE CYCLOOXYGENASE-2 INHIBITOR, COLORECTAL-CANCER CELLS, COX-2 INHIBITOR, POTENTIAL ROLE, GROWTH, EXPRESSION, APOPTOSIS, LYMPHOMA, CARCINOMA
  • Gazi Üniversitesi Adresli: Evet

Özet

Background: Non-steroidal anti-inflammatory drugs (NSAIDs) have been reported to induce apoptosis and inhibit cell proliferation in tumor cells when combined with conventional chemotherapeutic agents. We aimed to investigate the effect of NSAIDs (meloxicam and lornoxicam) plus conventional chemotherapeutic agents on RAF/MEK/ERK pathway in Burkitt's lymphoma cell line (Raji).