Synthesis of some new 2,6-disubstituted-3(2H)-pyridazinone derivatives and investigation of their analgesic, anti-inflammatory and antimicrobial activities

Tiryaki D., Sukuroglu M. K., DOĞRUER D. S., AKKOL E., Ozgen S., Sahin M. F.

MEDICINAL CHEMISTRY RESEARCH, cilt.22, sa.6, ss.2553-2560, 2013 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 22 Sayı: 6
  • Basım Tarihi: 2013
  • Doi Numarası: 10.1007/s00044-012-0253-1
  • Dergi Adı: MEDICINAL CHEMISTRY RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.2553-2560
  • Anahtar Kelimeler: 3(2H)-pyridazinone, Analgesic activity, Anti-inflammatory activity, Antimicrobial activity, INHIBITORS
  • Gazi Üniversitesi Adresli: Evet

Özet

In this study, 12 new 3(2H)-pyridazinone derivatives carrying 4-substituted phenylpiperazinylethyl moiety on lactam nitrogen were synthesized and their chemical structures were confirmed by H-1-NMR, mass, and elemental analysis. Analgesic and anti-inflammatory activities of the synthesized compounds were evaluated in mice. Among the synthesized compounds, compound 9c showed the best analgesic and anti-inflammatory activities without causing any gastric effect in stomachs of tested animals. In addition, the synthesized compounds were screened for their antibacterial and antifungal activities against some pathogenic strains.