Association of serum levels of IGF-I and IGFBP-1 with renal function in patients with type 2 diabetes mellitus


Akturk M., Arslan M., Altinova A., Ozdemir A., Ersoy R., Yetkin I., ...More

GROWTH HORMONE & IGF RESEARCH, vol.17, no.3, pp.186-193, 2007 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 17 Issue: 3
  • Publication Date: 2007
  • Doi Number: 10.1016/j.ghir.2007.01.007
  • Title of Journal : GROWTH HORMONE & IGF RESEARCH
  • Page Numbers: pp.186-193
  • Keywords: type 2 diabetes, insulin-like growth factor-I, insulin-like growth factor binding protein-1, creatinine clearance, urinary N-acetyl-beta-D-glucosaminidase, GROWTH-FACTOR-I, FACTOR BINDING PROTEIN-1, GLOMERULAR-FILTRATION-RATE, FACTOR SYSTEM COMPONENTS, CARDIOVASCULAR RISK, INSULIN, MICROALBUMINURIA, CHILDREN, FAILURE, DISEASE

Abstract

Objective: Our aim was to determine whether serum Insulin-like growth factor-I (IGF-I) and Insulin-like growth factor binding protein-1 (IGFBP-1) levels were different between type 2 diabetic patients and non-diabetic control group. We also aimed to establish any relationship that might exist between the serum IGF-I and IGFBP-1 levels with the urinary albumin excretion (UAE), creatinine clearance and urinary N-acetyl-beta-D-glucosaminidase (NAG) excretion (as a marker of renal tubular dysfunction) and other parameters (such as age, duration of diabetes, treatment, etc.) in patients with type 2 diabetes mellitus (DM).