Association of serum levels of IGF-I and IGFBP-1 with renal function in patients with type 2 diabetes mellitus

Akturk M. Y., Arslan M., Altinova A., Ozdemir A., Ersoy R., Yetkin I., ...Daha Fazla

GROWTH HORMONE & IGF RESEARCH, cilt.17, sa.3, ss.186-193, 2007 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 17 Sayı: 3
  • Basım Tarihi: 2007
  • Doi Numarası: 10.1016/j.ghir.2007.01.007
  • Dergi Adı: GROWTH HORMONE & IGF RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.186-193
  • Anahtar Kelimeler: type 2 diabetes, insulin-like growth factor-I, insulin-like growth factor binding protein-1, creatinine clearance, urinary N-acetyl-beta-D-glucosaminidase, GROWTH-FACTOR-I, FACTOR BINDING PROTEIN-1, GLOMERULAR-FILTRATION-RATE, FACTOR SYSTEM COMPONENTS, CARDIOVASCULAR RISK, INSULIN, MICROALBUMINURIA, CHILDREN, FAILURE, DISEASE
  • Gazi Üniversitesi Adresli: Evet

Özet

Objective: Our aim was to determine whether serum Insulin-like growth factor-I (IGF-I) and Insulin-like growth factor binding protein-1 (IGFBP-1) levels were different between type 2 diabetic patients and non-diabetic control group. We also aimed to establish any relationship that might exist between the serum IGF-I and IGFBP-1 levels with the urinary albumin excretion (UAE), creatinine clearance and urinary N-acetyl-beta-D-glucosaminidase (NAG) excretion (as a marker of renal tubular dysfunction) and other parameters (such as age, duration of diabetes, treatment, etc.) in patients with type 2 diabetes mellitus (DM).