Evaluation of matrix metalloproteinase-1 and tissue inhibitor of metalloproteinase-1 levels in gingival fibroblasts of cyclosporin A-treated patients

Tuter G., SERDAR M. A., Yalim M., Gurhan I., Balos K.

JOURNAL OF PERIODONTOLOGY, cilt.73, sa.11, ss.1273-1278, 2002 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 73 Sayı: 11
  • Basım Tarihi: 2002
  • Doi Numarası: 10.1902/jop.2002.73.11.1273
  • Dergi Adı: JOURNAL OF PERIODONTOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1273-1278
  • Anahtar Kelimeler: cyclosporin A/adverse effects, matrix metalloproteinases, matrix metalloproteinase tissue inhibitors, gingival hyperplasia/pathogenesis, RENAL-TRANSPLANT PATIENTS, CREVICULAR FLUID, GENE-EXPRESSION, GROWTH-FACTOR, MESSENGER-RNA, OVERGROWTH, COLLAGENASE, PERIODONTITIS, HYPERPLASIA, PHENOTYPE
  • Gazi Üniversitesi Adresli: Hayır

Özet

Background: Cyclosporin A (CsA) is a potent immunosuppressant used to prevent organ transplant rejection and to treat various autoimmune diseases. CsA-induced gingival overgrowth (CsA GO) is the most widely seen side effect of this drug; its pathogenesis is not completely understood. The aim of this study was to identify and compare matrix metalloproteinase-1 (MMP-1) and tissue inhibitor of metalloproteinase-1 (TIMP-1) levels in gingival fibroblast cultures of tissues derived from renal transplant patients receiving CsA and exhibiting gingival overgrowth and from periodontally healthy control subjects.