Effect of tyrosine-rich amelogenin peptide on behavior and differentiation of endothelial cells

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Jonke E., Gemperli A. C., Zhang T., Ozdemir B., Dard M., Rausch-Fan X., ...Daha Fazla

CLINICAL ORAL INVESTIGATIONS, cilt.20, sa.8, ss.2275-2284, 2016 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 20 Sayı: 8
  • Basım Tarihi: 2016
  • Doi Numarası: 10.1007/s00784-016-1726-2
  • Dergi Adı: CLINICAL ORAL INVESTIGATIONS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.2275-2284
  • Anahtar Kelimeler: Enamel matrix derivative, Wound healing, Endothelial cells, Angiogenesis, PERIODONTAL-LIGAMENT CELLS, ENAMEL MATRIX PROTEINS, IN-VITRO, GROWTH-FACTOR, ANGIOGENIC ACTIVITY, ADHESION MOLECULES, DENTAL-TISSUES, REGENERATION, MODEL, EXPRESSION
  • Gazi Üniversitesi Adresli: Evet

Özet

Enamel matrix derivative (EMD) is an effective biomaterial for periodontal tissue regeneration and might stimulate angiogenesis. Tyrosine-rich amelogenin peptide (TRAP) is present in EMD and is thought to contribute in its biological activity. In the present study, we investigated the effect of chemically synthesized TRAP on proliferation, migration, angiogenic structure formation, and differentiation of human umbilical vein endothelial cells (HUVECs) in vitro.