Akademik Veri Yönetim Sistemi
3rd International Gazi Pharma Symposium Series, Ankara, Türkiye, 8 - 10 Eylül 2021, ss.95
High consumption of fructose, particularly in the form of soft drinks, may contribute to the high prevalence of metabolic disorder. Fructose-induced metabolic disturbance is more likely to abdominal fat accumulation, but independent of general obesity. Kefir, a fermented milk product, consumption was reported to have beneficial effects in several disease models. The aim of the present study was to investigate the influence of kefir supplementation on lipogenesis-related factors in adipose tissue of high-fructose-fed rats. Fructose was given to the rats as a 20% solution in drinking water for 15 weeks. Kefir was administrated by gastric gavage once a day during the final six weeks. Gene expressions were determined by real-time PCR. There was an upregulation of ANGPTL8 mRNA expression in adipose tissue of rats given fructose. However, expressions of PI3K, mTOR, and PPARy mRNAs were impaired in the adipose tissue. Kefir supplementation suppressed expression of ANGPTL8, but increased PI3K and mTOR in adipose tissue of high-fructose-fed rats. Kefir supplementation has modulatory effects on fructose-induced changes except forPPARy expression. These findings showed that dietary fructose and kefir might reciprocally affect the lipogenesis-related genes in the adipose tissue.