Tp-e interval and Tp-e/QT ratio in patients with Human Immunodeficiency Virus


Unal S., Yayla C., Acar B., Ertem A. G., Akboga M. K., Gokaslan S., ...Daha Fazla

JOURNAL OF INFECTION AND PUBLIC HEALTH, cilt.11, sa.1, ss.35-38, 2018 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 11 Sayı: 1
  • Basım Tarihi: 2018
  • Doi Numarası: 10.1016/j.jiph.2017.02.008
  • Dergi Adı: JOURNAL OF INFECTION AND PUBLIC HEALTH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.35-38
  • Anahtar Kelimeler: Human Immunodeficiency Virus, Tp-e interval, Tp-e/QT ratio, HIV-INFECTED PATIENTS, ANTIRETROVIRAL THERAPY, QT PROLONGATION, AORTIC-STENOSIS, RISK-FACTORS, TPEAK-TEND, HEART, CARDIOMYOPATHY, ARRHYTHMIAS, DISPERSION
  • Gazi Üniversitesi Adresli: Hayır

Özet

Human Immunodeficiency Virus (HIV) infection and AIDS are known to cause cardiovascular diseases such as premature coronary artery disease, cardiomyopathy, and arrhythmias. Recently, Tp-e interval and Tp-e/QT ratio has been shown as a novel marker of ventricular repolarization. We aimed to evaluate the ventricular repolarization using Tp-e interval and Tp-e/QT ratio in patients with Human Immunodeficiency Virus (HIV) infection. Totally 48 patients with HIV and 60 control subjects were enrolled to the study. Tp-e interval, Tp-e/QT and Tp-e/QTc ratio were measured from the 12-lead electrocardiogram. Tp-e interval, Tp-e/QT ratio and Tp-e/QTc ratio were significantly higher in patients with HIV than control subjects (all p < 0.01). In correlation analysis, there were positive correlation between Tp-e interval and disease duration (r = 0.298, p = 0.048). and inverse correlation between Tp-e interval and CD4 count(r = 0.303, p = 0.036). Our study showed that Tp-e interval, Tp-e/QT and Tp-e/QTc ratios were increased in patients with HIV than control subjects. (C) 2017 Published by Elsevier Limited on behalf of King Saud Bin Abdulaziz University for Health Sciences. This is an open access article under the CC BY-NC-ND license