Antioxidants alleviate electric field-induced effects on lung tissue based on assays of heme oxygenase-1, protein carbonyl content, malondialdehyde, nitric oxide, and hydroxyproline


Gueler G., Tuerkoezer Z., ÖZGÜR BÜYÜKATALAY E. , Seyhan N.

SCIENCE OF THE TOTAL ENVIRONMENT, cilt.407, sa.4, ss.1326-1332, 2009 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 407 Konu: 4
  • Basım Tarihi: 2009
  • Doi Numarası: 10.1016/j.scitotenv.2008.10.050
  • Dergi Adı: SCIENCE OF THE TOTAL ENVIRONMENT
  • Sayfa Sayıları: ss.1326-1332

Özet

In order to test whether antioxidants have beneficiary effects on electric field induced damage, we determined the pulmonary levels of heme oxygenase-1 (HO-1), protein carbonyl content (PCO), malondialdehyde (MDA), nitric oxide (NO) and hydroxyproline (HP) under extremely low frequency (ELF) electric (E) field exposure (50 Hz, 12 kV/m, 7 days/for 8 h/day). While PCO levels significantly increased (p<0.05), insignificant changes (p>0.05) were observed in HO-1, MDA, NO and HP levels for electric field exposure groups compared to the control group. We have not observed any significant change in these parameters on the electric field group compared to the group where NAC and EGCG were separately applied along with electric field. However, during our previous studies, we have concluded that NAC and EGCG are potent antioxidants and we believe that new studies should be established by way of setting up different experimental conditions. (C) 2008 Elsevier B.V. All rights reserved.