JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS, vol.52, no.2, pp.623-629, 2022 (SSCI)
Article / Article
JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
Social Sciences Citation Index (SSCI), Scopus, Academic Search Premier, ASSIA, PASCAL, BIOSIS, Child Development & Adolescent Studies, CINAHL, EBSCO Education Source, Education Abstracts, Educational research abstracts (ERA), EMBASE, ERIC (Education Resources Information Center), Linguistics & Language Behavior Abstracts, MEDLINE, Psycinfo, Public Affairs Index
Zonulin, Autism spectrum disorder, Gastrointestinal symptom, SPECTRUM DISORDERS, TIGHT JUNCTIONS, CELIAC-DISEASE, INTESTINAL PERMEABILITY, LARAZOTIDE ACETATE, GLUTEN, PATHOGENESIS, MODULATOR, BARRIER, BLIND
Gazi University Affiliated:
To evaluate the relationship between the severity of autism, severity of gastrointestinal symptoms and serum zonulin levels as a marker of increased intestinal permeability in children. Serum zonulin levels were determined in 56 children with ASDs and 55 healthy children. The severity of gastrointestinal symptoms and ASD symptoms was assessed with the Gastrointestinal Symptom Rating Scale (GSRS) and Childhood Autism Rating Scale (CARS), respectively. Serum zonulin levels were significantly higher than healthy controls in children with severe autism. A positive correlation was found between the CARS score, GSRS score and serum zonulin levels (r = ; P < .001). Our findings suggest that the severity of gastrointestinal symptoms and severity of autism might be related to increased intestinal permeability in ASDs children.